Rigid demand value under low toxicity and high solubility characteristics: Dichloromethane fine field application logic and low toxicity and high solubility characteristics Rigid demand value under: Dichloromethane fine field application logic and compliance boundary analysis compliance boundary analysis

Preface: The precision value of double-sided chemicals - irreplaceability under toxicological shortcomings Preface: The precision value of double-sided chemicals - irreplaceability under toxicological shortcomings

In the chemical industry, dichloromethane is a highly differentiated special solvent: both in the chemical industry, dichloromethane is a highly differentiated special solvent: both strong broad-spectrum solubility, very low combustion risk, relatively low toxicity, low-temperature volatile no residue strong broad-spectrum solubility, very low combustion risk, relatively low toxicity, low-temperature volatile no residue four core advantages. Unlike the single performance advantage of benzene, esters, and alkane solvents, dichloromethane achieves a precise balance of dissolution efficiency, process safety, and product purity. Due to this, although it is a controlled toxic chemical with health and environmental risks, it still cannot be completely replaced in rigid demand fields such as pharmaceutical refining, high-end chemical synthesis, fine additive production, and special industrial manufacturing, forming a unique industrial pattern of "knowing that it is slightly toxic, but irreplaceable". Four core advantages. Different from the single performance advantage of benzene series, esters, and alkane solvents, dichloromethane achieves a precise balance of dissolution efficiency, process safety, and product purity. Due to this, although it is a controlled toxic chemical and poses health and environmental risks, it cannot be completely replaced in rigid demand fields such as pharmaceutical refining, high-end chemical synthesis, fine additive production, and special industrial manufacturing, forming a unique industrial pattern of "knowing that it is slightly toxic, but irreplaceable".

Different from the conventional physical property science, market review, and trade crisis analysis in the industry, this paper focuses on dichloromethane, which is different from the conventional physical property science, market review, and trade crisis analysis in the industry. This paper focuses on dichloromethane subdivision of rigid demand application of underlying logic, process adaptation principle in various fields, compliance red line and use boundary, pharmaceutical grade product quality control value subdivision of rigid demand application of underlying logic, process adaptation principle in various fields, compliance red line and use boundary, pharmaceutical grade product quality control value , deep dismantling of its "sea inclusive" dissolution adaptation ability, and the unique core value in the field of fine chemicals., deep dismantling of its "sea inclusive" dissolution adaptation ability, and the unique core value in the field of fine chemicals.

1. Industry demand cycle review: rigid and rigid demand characteristics fluctuating with the industrial boom 1. Industry demand cycle review: rigid and rigid demand characteristics fluctuating with the industrial boom

2014-2019 was a steady expansion cycle for domestic dichloromethane fine app stores. With the upgrading of the domestic pharmaceutical industry, the large-scale development of high-end manufacturing, and the popularization of new polyurethane materials, the consumption of downstream rigid demand continued to grow steadily, and the industry as a whole was in an incremental upward stage. In 2020, due to the impact of global public health events, the start-up of the whole industry chain was limited, import and export logistics was blocked, and the production of end-point manufacturing was reduced, and the overall consumption of dichloromethane declined significantly in stages. 2014-2019 was a steady expansion cycle for domestic dichloromethane fine app stores. With the upgrading of the domestic pharmaceutical industry, the large-scale development of high-end manufacturing, and the popularization of new polyurethane materials, the consumption of downstream rigid demand continued to grow steadily In 2020, due to the impact of global public health events, the start of the whole industrial chain was limited, import and export logistics was blocked, and the end point manufacturing industry reduced production, and the overall consumption of dichloromethane decreased significantly in stages.

In 2021, the domestic economy will recover rapidly, and the chemical, pharmaceutical, and new material industries will fully enter the boom upward channel. The downstream demand for fine synthesis, drug refining, and high-end material production will pick up, and the demand for dichloromethane will gradually recover. This cycle change fully confirms that dichloromethane is not a low-end consumable chemical product, but the domestic economy will recover rapidly in 2021. The chemical, pharmaceutical, and new material industries will fully enter the boom upward channel. The downstream demand for fine synthesis, drug refining, and high-end material production will pick up, and the demand for dichloromethane will gradually recover. This cycle change fully confirms that dichloromethane is not a low-end consumable chemical, but a binding high-end fine manufacturing rigid demand supporting raw materials binding high-end fine manufacturing rigid demand supporting raw materials , demand fluctuates with the high-end industrial cycle, with extremely strong rigid support attributes, short-term macro shocks only affect short-term consumption, and cannot shake the long-term rigid demand foundation., demand fluctuates with the high-end industrial cycle, with extremely strong rigid support attributes, short-term macro shocks only affect short-term consumption, and cannot shake the long-term rigid demand foundation.

2. Core trait analysis: three exclusive advantages in the fine field of adaptation 2. Core trait analysis: three exclusive advantages in the fine field of adaptation

Dichloromethane can span a variety of high-end fine fields. The core reason is its unique physical and chemical adaptability that is different from conventional solvents, and it is also the bottom support for its dissolution ability. Dichloromethane can span a variety of high-end fine fields. The core reason is its unique physical and chemical adaptability that is different from conventional solvents, and it is also the bottom support for its dissolution ability.

First, first, Broad spectrum super dissolution compatibility Broad spectrum super dissolution compatibility . As a moderately polar halogenated hydrocarbon solvent, it is compatible with most organic substances such as polymer resins, oils, esters, alkaloids, photosensitive materials, medical polymers, etc. It has a fast dissolution rate, stable solution system, and will not have side reactions with solutes. It is suitable for various fine synthesis, purification, and extraction processes... As a moderately polar halogenated hydrocarbon solvent, it is compatible with most organic substances such as polymer resins, oils, esters, alkaloids, photosensitive materials, and medical polymers. It has a fast dissolution rate, stable solution system, and will not have side reactions with solutes. It is suitable for various fine synthesis, purification, and extraction processes.

Second, second, Low toxicity and excellent resuscitation Low toxicity and excellent resuscitation . Compared with traditional solvents such as benzene, ether, and petroleum ether, dichloromethane has lower acute toxicity and fast recovery after human mild exposure to poisoning. It is one of the few low-risk solvents that can be used in the production of human-related medicines and daily chemical additives. It is perfectly adapted to the safety bottom line requirements of biomedicine... Compared with traditional solvents such as benzene, ether, and petroleum ether, dichloromethane has lower acute toxicity and fast recovery after human mild exposure to poisoning. It is one of the few low-risk solvents that can be used in the production of human-related medicines and daily chemical additives. It is perfectly adapted to the safety bottom line requirements of biomedicine.

Third, third, Low temperature volatile, no residual pollution Low temperature volatile, no residual pollution . Boiling point is only 39.8 ° C, low temperature can be completely volatilized, no need to bake at high temperature, will not destroy the heat-sensitive drug activity and polymer material structure, completely avoid high temperature degradation and product deterioration problems, is the exclusive suitable solvent for the production of heat-sensitive fine products..... Boiling point is only 39.8 ° C, low temperature can be completely volatilized, no need to bake at high temperature, will not destroy the heat-sensitive drug activity and polymer material structure, completely avoid high temperature degradation and product deterioration problems, is the exclusive suitable solvent for the production of heat-sensitive fine products.

III. Full-scene fine application deep disassembly: process principle and core value III. Full-scene fine application deep disassembly: process principle and core value

3.1 General Industrial Field: Low-cost, high-safety basic process support 3.1 General Industrial Field: Low-cost, high-safety basic process support

In traditional industrial scenarios, dichloromethane has become a core additive for lightweight and safe production due to its non-flammability, low residue, and high degreasing solubility. In the field of polymer materials, film-forming solvents for the production of safety film and polycarbonate can precisely control the viscosity and uniformity of coating formation to ensure material light transmittance and structural stability; in the field of surface treatment, as a high-end metal degreaser, paint paint remover, aerosol spray agent, the cleaning efficiency far exceeds that of conventional solvents, and there is no risk of flammability and explosion; in the field of new material foaming, it is suitable for the auxiliary foaming process of polyurethane foam and polysulfone foam, so that the foam pores are uniform and fine, and the toughness and stability of materials are improved; in the field of refrigeration, it is used for low-pressure freezers, air-conditioning refrigeration systems, and can be used for grain fumigation, disinfection and sterilization, taking into account industrial production and people's livelihood In traditional industrial scenarios, dichloromethane has become a core additive for lightweight and safe production due to its non-flammability, low residue, and high degreasing solubility. In the field of polymer materials, film-forming solvents for the production of safety film and polycarbonate can precisely control the viscosity and uniformity of coating formation to ensure material light transmittance and structural stability; in the field of surface treatment, as a high-end metal degreaser, paint paint remover, aerosol spray agent, the cleaning efficiency far exceeds that of conventional solvents, and there is no risk of flammability and explosion; in the field of new material foaming, it is suitable for the auxiliary foaming process of polyurethane foam and polysulfone foam, so that the foam pores are uniform and fine, and the toughness and stability of materials are improved; in the field of refrigeration, it is used for low-pressure freezers, air-conditioning refrigeration systems, and can be used for grain fumigation, disinfection and sterilization, taking into account industrial production and people's livelihood disinfection and steril

3.2 Cosmetic additives field: optimal solution to replace highly toxic benzene-based solvents (compliance boundary analysis) 3.2 Cosmetic additives field: optimal solution to replace highly toxic benzene-based solvents (compliance boundary analysis)

Carbomer is the core emulsion thickener of emulsions, creams, gels and other cosmetics. Its synthesis process requires extremely high solvent solubility, stability and residue rate. The traditional process uses benzene as the solvent, but benzene belongs to a strong class of carcinogens, and countries have long prohibited its use in the production of daily chemical raw materials. Dichloromethane has become the core emulsion thickener of carbomer in the production process of carbomer. Carbomer is the core emulsion thickener of emulsions, creams, gels and other cosmetics. Its synthesis process requires extremely high solvent solubility, stability and residue rate. The traditional process uses benzene as the solvent, but benzene belongs to a strong class of carcinogens, and countries have long been strictly prohibited from using it in the production of daily chemical raw materials. With its strong solubility and stable reaction inertness, dichloromethane has become the only cost-effective optimal solution to replace benzene-based solvents in the production process of Carbomer . The only cost-effective optimal solution to replace benzene-based solvents , is widely used in the synthesis process of daily chemical additives., widely used in the synthesis process of daily chemical additives.

Key compliance boundaries need to be clarified here: The national "Key Control New Pollutants List (2023 Edition) " and cosmetic safety technical specifications clearly stipulate that key compliance boundaries need to be clarified here: The national "Key Control New Pollutants List (2023 Edition) " and cosmetic safety technical specifications clearly stipulate that dichloromethane is strictly prohibited from being added directly as a cosmetic component to the finished product. Dichloromethane is strictly prohibited from being added directly as a cosmetic component to the finished product , but it can be used as a process aid and reaction solvent in the production process of raw materials. It is completely removed through volatilization and purification, and the finished product has no residue, which belongs to the compliance process application. This is also the core reason why it has a huge demand in the cosmetics industry chain, but does not touch the safety red line., but it can be used as a process aid and reaction solvent in the production process of raw materials, and then completely removed by volatilization and purification, and the finished product has no residue, which belongs to the compliance process application. This is also the core reason why it has a huge demand in the cosmetics industry chain, but does not touch the safety red line.

3.3 Pharmaceutical Field: Rigid Demand Carrier for Thermal Drug Synthesis and Refinement 3.3 Pharmaceutical Field: Rigid Demand Carrier for Thermal Drug Synthesis and Refinement

The pharmaceutical field is the core scenario with the highest added value and the strongest irreplaceability of dichloromethane. The core adaptation pharmaceutical field is the core scenario with the highest added value and the strongest irreplaceability of dichloromethane. The core adapts to the production needs of thermosensitive drugs, antibiotics, biologics Thermosensitive drugs, antibiotics, biologics , and completely solves the process pain points of traditional flammable and highly toxic solvents. The production needs of completely solve the process pain points of traditional flammable and highly toxic solvents.

In antibiotic synthesis, as the exclusive reaction medium for mainstream antibiotics such as ampicillin, oxybenicillin, and pioneer mycin, the whole process is low-temperature inert reaction, does not participate in the side reactions of drug synthesis, and retains the drug activity to the greatest extent and reduces the impurity generation rate. In the field of drug purification, instead of flammable solvents such as ether and petroleum ether, it is used for low-temperature extraction of pharmaceutical active substances, fats, and oils. The safety is greatly improved, and it is suitable for the dust-free and explosion-proof production environment requirements of medicine. In antibiotic synthesis, as the exclusive reaction medium for mainstream antibiotics such as ampicillin, oxybenicillin, and pioneer mycin, the whole process is low-temperature inert reaction, does not participate in the side reactions of drug synthesis, and retains the In the field of drug purification, instead of ether, petroleum ether and other flammable solvents, it is used for low temperature extraction of pharmaceutical active substances, fats and oils, and the safety is greatly improved. It is suitable for the dust-free and explosion-proof production environment requirements of medicine.

At the same time, based on its low toxicity and rapid recovery after poisoning, dichloromethane has been used in the production of dental local anesthesia preparations. With its mild anesthesia effect and low accumulation toxicity, it ensures the safety of medical use and is a typical representative of fine medical solvents. At the same time, based on its low toxicity and rapid recovery after poisoning, dichloromethane has been used in the production of dental local anesthesia preparations. With its mild anesthesia effect and low accumulation toxicity, it ensures the safety of medical use and is a typical representative of fine medical solvents.

IV. High-end application examples of medicine: irreplaceable value in precision technology IV. High-end application examples of medicine: irreplaceable value in precision technology

From the perspective of specific drug synthesis processes, the suitability of dichloromethane cannot be replaced by conventional solvents, and it plays a core process role in the production of many blockbuster drugs, directly determining product purity and yield. From the perspective of specific drug synthesis processes, the suitability of dichloromethane cannot be replaced by conventional solvents, and it plays a core process role in the production of many blockbuster drugs, directly determining product purity and yield.

Example 1: Preparation of Tazobactam (recovery of key intermediates of antibiotics) Example 1: Preparation of Tazobactam (recovery of key intermediates of antibiotics) . Tazobactam is a commonly used β-lactamase inhibitor in clinical practice. The key step of deprotection requires dissolving 3,5-dinitrobenzyl ester raw materials in dichloromethane and completing the reduction reaction through hydrogen gas. After the reaction, relying on the precise selective dissolution and low temperature volatilization characteristics of dichloromethane, the by-product 3,5-dinitrotoluene is efficiently recovered to achieve the recycling of raw materials, which not only guarantees the purity of drug intermediates, but also reduces production costs. No other solvents can achieve the same recovery effect... Tazobactam is a commonly used β-lactamase inhibitor in clinical practice. The key process of deprotection requires the dissolution of 3,5-dinitrobenzyl ester raw material in dichloromethane and the reduction reaction is completed by hydrogen. After the reaction, relying on the precise selective dissolution and low temperature volatilization characteristics of dichloromethane, the by-product 3,5-dinitrotoluene is efficiently recovered, and the raw material is recycled, which not only ensures the purity of drug intermediates, but also reduces production costs. The same recovery effect can be achieved without other solvents.

Example 2: Synthesis of oxiracetam (refining of nerve drugs) Example 2: Synthesis of oxiracetam (refining of nerve drugs) . Oxiracetam, as a core drug to improve brain metabolism, relies on dichloromethane in its three key synthesis processes: preparation of the intermediate ethyl acetate, purification of the intermediate of hydroxypyrrolidone, and synthesis and purification of the final product. The inert medium properties of dichloromethane can avoid acid-base side reactions, accurately purify the target product, and control the impurity content of the drug. It is the core process solvent to ensure the stability of the efficacy of oxiracetam... Oxiracetam, as a core drug for improving brain metabolism, relies on dichloromethane in three key synthesis processes: the preparation of the intermediate ethyl acetate, the purification of the intermediate hydroxypyrrolidone, and the synthesis and purification of the final product. The inert medium properties of dichloromethane can avoid acid-base side reactions, accurately purify the target product, and control the content of drug impurities. It is the core process solvent to ensure the efficacy and stability of oxiracetam.

Example 3: Preparation of Leupropirelin Acetate Microspheres (Core Process of Sustained-Release Preparation) Example 3: Preparation of Leupropirelin Acetate Microspheres (Core Process of Sustained-Release Preparation) . The core carrier of this long-acting sustained-release preparation is PLGA polymer material. Conventional solvents cannot completely dissolve PLGA or destroy the sustained-release structure of the material, while dichloromethane can gently dissolve PLGA to ensure uniform microsphere molding and stable slow-release cycle. It is a rigid required solvent for the production of long-acting polypeptide sustained-release preparations, which directly determines the sustained-release effect and clinical efficacy of drugs... The core carrier of the long-acting sustained-release preparation is PLGA polymer material. Conventional solvents cannot completely dissolve PLGA or destroy the sustained-release structure of the material, while dichloromethane can gently dissolve PLGA to ensure uniform microsphere molding and stable sustained-release cycle. It is a rigid demand solvent for the production of long-acting polypeptide sustained-release preparations, which directly determines the sustained-release effect and clinical efficacy of the drug.

5. Fine area compliance use logic and high-end product quality control value 5. Fine area compliance use logic and high-end product quality control value

The industry controversy of dichloromethane is essentially the industry dispute of dichloromethane, and the essence is The confusion between the cognition of low-end abuse and high-end rigid demand . In low-end scenarios such as paint stripping and civil cleaning, its high-pollution and high-risk attributes are prominent, and it belongs to the scene of the state's explicit elimination; but in fine fields such as pharmaceutical refining, high-end additive synthesis, and special material production, its process value is irreplaceable. As long as closed-loop control, residual control, and waste gas disposal are done well, safety compliance applications can be realized... In low-end scenarios such as paint removal and civil cleaning, its high pollution and high risk attributes are highlighted, and it belongs to the scene of national elimination; but in fine fields such as pharmaceutical refining, high-end additive synthesis, and special material production, its process value is irreplaceable. As long as closed-loop control, residual control, and waste gas disposal are done well, safety compliance applications can be realized.

The fine field has extremely high requirements for the purity, impurities and residues of dichloromethane, and industrial-grade products cannot meet the production standards of pharmaceuticals and daily chemical additives. Taking CG's pharmaceutical-grade dichloromethane as an example, it is produced under the GMP specification system and fully complies with the European Pharmacopoeia standards. The impurity content is extremely low and the purity is stable. It can provide a full set of third-party audit reports. It can adapt to the quality management system of pharmaceutical companies and high-end daily chemical companies, and avoid the risk of solvent residues and impurities exceeding the standard from the source. It is the core supporting raw material for the high-end development of fine chemicals. The fine field has extremely high requirements for the purity, impurities and residues of dichloromethane, and industrial-grade products cannot meet the production standards Taking CG's pharmaceutical-grade dichloromethane as an example, it is produced under the GMP specification system, fully complies with the European Pharmacopoeia standards, has extremely low impurity content, stable purity, and can provide a full set of third-party audit reports, which can be adapted to the quality management system of pharmaceutical companies and high-end daily chemical enterprises. It avoids the risk of solvent residue and impurity exceeding the standard from the source, and is the core supporting raw material for the high-end development of fine chemicals.

6. Summary of the core views of the industry 6. Summary of the core views of the industry

The industrial value of dichloromethane cannot be unilaterally defined by toxicity labels alone. It is a typical industrial value of dichloromethane in the chemical industry, and cannot be unilaterally defined by toxicity labels alone. It is a typical "restricted rigid demand solvent" "restricted rigid demand solvent" in the chemical industry : The risk of low-end extensive scenarios is prominent, and it should be limited and eliminated. The performance of high-end fine scenes is unique and irreplaceable. The comprehensive advantages of its "Haina Baichuan" dissolution characteristics, low temperature no residue, low toxicity and safety, accurately match the core process requirements of high-end manufacturing such as pharmaceutical refining, high-end daily chemical additives, and special polymer materials, and are an important basic raw material to support the development of domestic fine chemical and biomedical industries.: The risk of low-end extensive scenes is prominent, and it should be limited and eliminated. The performance of high-end fine scenes is unique and irreplaceable. The comprehensive advantages of its "Haina Baichuan" dissolution characteristics, low temperature no residue, low toxicity and safety, and accurately match the core process requirements of high-end manufacturing such as pharmaceutical refining, high-end daily chemical additives, and special polymer materials, are important basic raw materials to support the development of domestic fine chemical and biomedical industries.

The core logic of future industry development is not a complete ban on dichloromethane, but the core logic of future industry development. It is not a complete ban on dichloromethane, but a scenario-based control, hierarchical application, high-end purification, closed-loop governance scenario-based control, hierarchical application, high-end purification, closed-loop governance , eliminate low-end abuse scenarios, retain and standardize high-end fine rigid demand scenarios, rely on high-purity pharmaceutical-grade and electronic-grade product iteration, release the core value of its fine field, and achieve a balanced development of industrial value and safety and environmental protection., eliminate low-end abuse scenarios, retain and standardize high-end fine rigid demand scenarios, rely on high-purity pharmaceutical-grade and electronic-grade product iteration, release the core value of its fine field, and realize industrial value and safety and environmental protection Balanced development.

References References

1. Baidu Encyclopedia 1. Baidu Encyclopedia

2. [Dichloromethane]: Analysis of downstream demand for dichloromethane, Longzhong Information 2. [Dichloromethane]: Analysis of downstream demand for dichloromethane, Longzhong Information

3. "Safety Evaluation of Dichloromethane in Cosmetics", Li Haoming, Tang Jiawen, Li Xuezhu, "Science of Daily Chemicals" 3. "Safety Evaluation of Dichloromethane in Cosmetics", Li Haoming, Tang Jiawen, Li Xuezhu, "Science of Daily Chemicals"

4. "Identification of Organic Drug Mass Spectrometry", editor-in-chief of He Zunshi et al. 4. "Identification of Organic Drug Mass Spectrometry", editor-in-chief of He Zunshi et al.

5, CN109721617A, "A method for preparing tazobactam", Li Baoyong, Hao Chunbo, Su Qianzhen, Fan Changying, Sun Zhengjun 5, CN109721617A, "A method for preparing tazobactam", Li Baoyong, Hao Chunbo, Su Qianzhen, Fan Changying, Sun Zhengjun

6, CN201910100436, "A Leupropirelin Acetate Microsphere Preparation and Preparation Method", Yu Kongtong, Jiang Chaojun 6, CN201910100436, "A Leupropirelin Acetate Microsphere Preparation and Preparation Method", Yu Kongtong, Jiang Chaojun

7. "List of Key Control New Pollutants (2023 Edition) ", Ministry of Ecology and Environment 7. "List of Key Control New Pollutants (2023 Edition) ", Ministry of Ecology and Environment

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